Dr. Cha is the Distinguished Investigator and Director of the National Institute of Cancer Research, National Health Research Institute, Professor of the Division of Urology, Department of Surgery, TSGH, NDMC, as well as Jointly Appointed Professor of Genomics Research Center, Academia Sinica. Dr. Cha received his MD degree from the School of Medicine, National Defense Medical Center in 1990. He got his PhD degree from GSBS, The University of Texas, MD Anderson Cancer Center in 2005. Upon his return to Taiwan, he served as a surgeon-scientist dedicated to cancer diagnosis and treatment, along with his active participation in international anti-cancer drug development clinical trials worldwide, which has afforded him a profound understanding of the entire spectrum of cancer research. During his tenure as the full professor of the National Defense Medical Center, he was invited to be the convener of the Department of Nephrology, Urology, and Metabolism at the National Science Council, he possesses a comprehensive understanding of the nation's scientific research direction and key points that would contribute to the advancement and connection of the basic and clinical research. Dr. Cha has played numerous leadership roles in medicine and research. He served the Presidentship in NDMC and is a member of the Taiwan Medical Education Evaluation Committee, he strives to align Taiwan's medical education with international standards collaboratively. Additionally, his involvement in the Medical Policy Council, directorship and supervision of the Health Policy Council, and roles in the National Innovation Award's academic research and corporate innovation committees. He has served as the director of the Acer Foundation and the Revitalization Hospitals. He received the 2021 National Excellent Teacher Award from the Ministry of Education and was listed in the World’s Top 2% Scientists 2021. Dr. Cha’s research interests concentrated on unraveling the mechanisms of cancer metastasis and progression and discovering innovative cancer treatments. His lab uncovered a novel cancer mitochondrial regulatory mechanism and identified a drug combination targeting this mechanism. This study was transferred to a biotechnology company. After completing pre-clinical animal toxicity testing, this new drug combination obtained IND approval in Taiwan and the United States. Dr. Cha initiated and completed a Phase I clinical trial to assess the drug's safety and preliminary efficacy for patients with advanced kidney cancer and other cancers resistant to multiple drug treatments. The biotechnology company collaborated with six medical centers in Australia for Phase I and Phase IIa clinical trials, leading to the prestigious 13th National Innovation Award. Over the past decade, Dr. Cha’s Lab identified a novel G protein-coupled receptor, mediating the evolution of cancer metastasis in various cancer types. Dr. Cha elucidated the fundamental molecular mechanisms governing the transition of cancer cells from paracrine to autocrine signaling regulation through the novel GPCR pathway.